Intravenous drug abusers may incur bloodstream infections, in particular those involving the heart valves, that often require extended courses of antibiotics, commonly on the order of six weeks.Conventional wisdom has dictated that even when patients are sufficiently well to not need ongoing hospitalization, it is unsafe to complete their antibiotic course in any setting other than in a closely supervised facility, even if this is contrary to their wishes. The assumption has been that such patients would be at risk of (...) using their indwelling intravenous catheter for illicit purposes. Recent advances in the care of patients who suffer from addiction disorders suggest that when patients receive state-of-the-art addiction treatment, many may be able to continue their intravenous antibiotic course unsupervised, at home. This represents a departure from the parentalistic model of care of impaired patients who are prone to self-harm, moving towards a model that respects autonomy and trusts patients who are in recovery to continue their care in a manner that is self-beneficial. (shrink)

Researchers and practitioners are increasingly using machine‐generated synthetic data as a tool for advancing health science and practice, by expanding access to health data while—potentially—mitigating privacy and related ethical concerns around data sharing. While using synthetic data in this way holds promise, we argue that it also raises significant ethical, legal, and policy concerns, including persistent privacy and security problems, accuracy and reliability issues, worries about fairness and bias, and new regulatory challenges. The virtue of synthetic data is often understood (...) to be its detachment from the data subjects whose measurement data is used to generate it. However, we argue that addressing the ethical issues synthetic data raises might require bringing data subjects back into the picture, finding ways that researchers and data subjects can be more meaningfully engaged in the construction and evaluation of datasets and in the creation of institutional safeguards that promote responsible use. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Rhetoricians Identified:A Call to Interdisciplinary Action and How it Resonated in the Field of RhetoricChristine Isager and Sine Nørholm Just"I actually like this book a lot, but I am not sure how comfortable I am with liking it," wrote William Keith (1995, 488) in a review of the original 1993 edition of Steve Fuller's Philosophy, Rhetoric, and the End of Knowledge (PREK), in which rhetoric is invited to participate (...) in the interdisciplinary reconfiguration of Science and Technology Studies (STS). This hesitant enthusiasm aptly exemplifies how an interdisciplinary invitation is likely to make its addressees squirm as they watch their professional aims being defined and then redefined by a disciplinary outsider who points out a place for them in a novel disciplinary constellation. Moreover, and more specifically, Keith's comment exemplifies how PREK was received by rhetoricians. On the surface, the reviews were glowing. In Philosophy and Rhetoric as well as in Philosophy of the Social Sciences, Keith expressed certain doubts about Fuller's work, but still he described it as "important," "exceptional," "superb" (1996; 1995). In the Quarterly Journal of Speech, Kenneth S. Zagacki called PREK both "excellent" and "exciting" (1995), and he was backed by John Angus Campbell and Keith R. Benson a year later when the same journal included PREK in an omnibus review entitled "The Rhetorical Turn in Science Studies" (Campbell and Benson 1996). Like Alan Gross, who reviewed the book in College English together with a number of works on workplace writing (1994), Campbell and Benson placed PREK at the cutting edge of rhetorical theory.The initial excitement over PREK forms a sharp contrast to the quite negligible impact that the book has had on the field of rhetoric in the decade that has passed since it was first published. In this essay we will undertake a close reading of the book along with the five above-mentioned reviews, looking for an explanation of the peculiar fate that met Steve [End Page 248] Fuller's proposal in the rhetorical disciplinary context. Our conclusion is that on reading the book, rhetoricians felt so flattered by Fuller's confident handling of rhetoric that the task of introducing and applying rhetorical theory in STS seemed, on the whole, to have been done for them. Furthermore, Fuller's attempts to construct a rhetorical agency are subverted by his idiosyncratic, i.e., inimitable, professional approach, which is also reflected in his style of writing. At once presumptuous and colloquial, his rhetoric serves to impress and entertain, but it fails to engage his audience substantially and to enact the interpenetrative stance that was intended to be the hallmark of PREK and that continues to be the commendable chief concern of Steve Fuller and his fellow social epistemologists.Text-Intertext and IdentificationInterdisciplinary invitations or, rather, interdisciplinary inspirational works of science were originally described as a noteworthy rhetorical genre by Leah Ceccarelli (2001). Ceccarelli explores how claims to scientific unity have handled a primary constraint: their multiple audiences. Fuller explicitly positions PREK within the genre of interdisciplinary inspiration by asserting that "the success of this book... should be measured in terms of its ability to persuade philosophers, theoretical humanists and social scientists, STS practitioners, and rhetoricians of science to see each other as engaged in a common enterprise" (1993, xii-xiii). We will not, however, be examining PREK's ability to be strategically opaque (as Fuller puts it), polysemous(Ceccarelli's term), or otherwise adapted to address its multiple audiences. Instead, we focus solely on Fuller's address to rhetoricians and study how he identifies with this particular audience. Ceccarelli recognizes the importance of ethical appeal in interdisciplinary invitations by positing the establishment of both an authoritative and personal authorial persona as a generic criterion. We follow this lead and add a Burkean emphasis on identification.According to Kenneth Burke, identification is a prior condition for persuasion "precisely because there is division" (Burke 1969, 22). The speaker's success depends on his ability to imitate the ways of his audience and to create a common ground or perspective that makes collective action possible. Burke's work allows us to distinguish three rhetorical strategies of identification. The first strategy... (shrink)

We explore an unsolved challenge in the era of evidence-based medicine (EBM): the recognition of the patient as an epistemic agent or ‘knower’. While patients are increasingly acknowledged as carriers of values and preferences, it seems more challenging to acknowledge them as carriers of important causal information. In contrast, the science of pharmacovigilance depends on patient testimonies as valuable sources of causal evidence. This incompatibility can give rise to cases of what has been called participatory epistemic injustice. We analyse the (...) testimony of a chronic pain patient and co-author of this article, Christine. Christine gives an auto-ethnographic account of her interactions with healthcare professionals trying to find the right pharmacological treatment for her condition. Through the analysis of her own story, she identifies some relevant themes for the epistemic interaction between healthcare professionals and chronic pain patients. We argue that such epistemic interactions are increasingly shaped by EBM and its conception of causality, which devalues patient subjective testimonies and emphasises statistical evidence. We conclude that outlier patients face an inherent risk of being left vulnerable to participatory epistemic injustice, particularly regarding the discovery of novel, rare adverse effects of medicines. (shrink)

Frequency effects are pervasive in studies of language, with higher frequency words being recognized faster than lower frequency words. However, the exact nature of frequency effects has recently been questioned, with some studies finding that contextual information provides a better fit to lexical decision and naming data than word frequency ( Adelman et al., 2006 ). Recent work has cemented the importance of these results by demonstrating that a measure of the semantic diversity of the contexts that a word occurs (...) in provides a powerful measure to account for variability in word recognition latency ( Johns et al., 2012, 2015 ; Jones et al., 2012 ). The goal of the current study is to extend this measure to examine bilingualism and aging, where multiple theories use frequency of occurrence of linguistic constructs as central to accounting for empirical results ( Gollan et al., 2008 ; Ramscar et al., 2014 ). A lexical decision experiment was conducted with four groups of subjects: younger and older monolinguals and bilinguals. Consistent with past results, a semantic diversity variable accounted for the greatest amount of variance in the latency data. In addition, the pattern of fits of semantic diversity across multiple corpora suggests that bilinguals and older adults are more sensitive to semantic diversity information than younger monolinguals. (shrink)

To examine the underlying processes of an innovative mind-body practice, Mindful Body Awareness, this exploratory study involved four case studies analyzed phenomenologically using the dialogal method. Mindful Body Awareness combines manual and verbal processing, and is focused on facilitation of client body awareness. Four individuals were recruited to receive weekly 1.25 hour sessions over four weeks. The Helpfulness Aspects of Therapy form was administered immediately after each session to access participants’ perceptions of the therapy experience. In addition, the Scale of (...) Body Connection was used to examine pre- and post-body awareness and bodily dissociation. Analysis involved phenomenology and descriptive statistics. The overall perceived helpfulness of the intervention was evident in the four themes that emerged from the analysis. These themes were gaining interoceptive awareness, personal agency, therapist trust and conceptual framing, and transformation. The participants’ responses were also used to investigate the therapy process across time. A pattern of increased interoceptive depth was apparent, as was a concomitant progression in embodied sense of self. Improvements in body awareness and bodily dissociation were evident for two of the four participants. These findings help to identify primary components of Mindful Body Awareness and suggest the role of these components in the embodiment process. (shrink)

A critical review of four recent works that reflect current conflicts and tensions among feminists regarding new reproductive technologies: In Search of Parenthood by Judith Lasker and Susan Borg; Ethics and Human Reproduction by Christine Overall; Made to Order, Patricia Spallone and Deborah Steinberg, eds. and Reproductive Technologies: Gender, Motherhood and Medicine, Michelle Stanworth, ed. Their positions are evaluated against the background of growing feminist dialogue about the future of reproduction and the bearing of reproductive innovations on such related issues (...) as racism, sexuality, motherhood and abortion. (shrink)

This paper provides an evolutionary rationale for both interracial and intraracial wage differentials by examining the implications of white employers mediating their employer?employee relationships on the basis of genetic similarity. If in organized labor markets; relationships mediated through genetic similarity are optimal in terms of Darwinian fitness, a fundamental evolutionary implication is that the Marginal Rate of Substitution (MRS) in Darwinian fitness holding extended fitness constant equals the MRS in preferences holding utility constant. Given such an evolutionary equilibrium, results are (...) derived showing that the strength of tastes for discrimination depends upon the skin hue of non?white workers. The rationale established for racial wage differentials is that where skin hue serves to indicate genetic similarity between employer and employee, wage differentials emerge that are a function of skin hue. (shrink)

Name der Zeitschrift: Byzantinische Zeitschrift Jahrgang: 107 Heft: 2 Seiten: 903-932.

Some metabolic pathways are nearly ubiquitous among organisms: the genes encoding the enzymes for such pathways must therefore be ancient and essential. De novo pyrimidine biosynthesis is an example of one such metabolic pathway. In animals a single protein called CADAbbreviations: CAD, trifunctional protein catalyzing the first three steps of de novo pyrimidine biosynthesis in higher eukaryotes; CPS, carbamyl phosphate synthetase domain; CPSase, carbamyl phosphate synthetase activity; ATC, aspartate transcarbamylase domain; ATCase, aspartate transcarbamylase activity; DHO, dihydroorotase domain; DHOase, dihydroorotase activity; (...) GLN, glutaminase subdomain or subunit of carbamyl phosphate synthetase, GL Nase, glutaminase activity; SYN, synthetase subdomain or subunit of carbamyl phosphate synthetase; SYNase, synthetase activity. carries the first three steps of this pathway. The same three enzymes in prokaryotes are associated with separate proteins. The CAD gene appears to have evolved through a process of gene duplication and DNA rearrangement, leading to an in‐frame gene fusion encoding a chimeric protein. A driving force for the creation of eukaryotic genes encoding multienzymatic proteins such as CAD may be the advantage of coordinate expression of enzymes catalyzing steps in a biosynthetic pathway. The analogous structure in bacteria is the operon. Differences in the translational mechanisms of eukaryotes and prokaryotes may have dictated the different strategies used by organisms to evolve coordinately regulated genes. (shrink)

This paper reviews the main pricing policies in Latin American countries, discussing their shortcomings. It also gives an overview of the most common pricing and reimbursement policies in Europe and describes in detail three well-established approaches — international price referencing, value-based pricing, including setting up of health technology assessment, and generic and biosimilar policies — building on country examples.

Researchers and practitioners are increasingly using machine-generated synthetic data as a tool for advancing health science and practice, by expanding access to health data while—potentially—mitigating privacy and related ethical concerns around data sharing. While using synthetic data in this way holds promise, we argue that it also raises significant ethical, legal, and policy concerns, including persistent privacy and security problems, accuracy and reliability issues, worries about fairness and bias, and new regulatory challenges. The virtue of synthetic data is often understood (...) to be its detachment from the data subjects whose measurement data is used to generate it. However, we argue that addressing the ethical issues synthetic data raises might require bringing data subjects back into the picture, finding ways that researchers and data subjects can be more meaningfully engaged in the construction and evaluation of datasets and in the creation of institutional safeguards that promote responsible use. (shrink)

The use of placebos in randomised controlled trials is a subject of considerable ethical debate. In this paper we present a set of considerations to evaluate the ethics of placebo controlled trials that includes: social value of the study; need for a randomised controlled trial and placebo; standards of care; risks of harm due to administration of placebo and the harm benefit balance; clinical equipoise; and double standards. We illustrate the application of these considerations using a case study of a (...) large ongoing multicentre, placebo-controlled, double-blinded, randomised trial to determine primaquine anti-relapse efficacy in vivax malaria. There is an urgent need for primaquine anti-relapse studies in order to rationalise the management of a potentially fatal disease. An ethical justification for the use of the placebo arm is provided on the grounds that the actual current applied standard of care in most endemic places does not include primaquine. It has also been argued that there is clinical equipoise among the primaquine study arms and that the risk of harms of being in the placebo arm is the risk of having relapse, which is no more than not being included in the trial, and that there are no double standards. Based on our set of considerations, we conclude that a placebo arm is not only justified but imperative in this study. We propose that similar considerations should be prospectively applied to other placebo controlled trials and observational control arms where no treatment is offered. (shrink)

Ce texte a d'abord paru en espagnol dans la revue Panambí. Revista de investigaciones artísticas, n. 4, Valparaíso, jun. 2017. Nous remercions Christine Esclapez de nous avoir autorisé à le reproduire ici. Introduction L'objectif de ma contribution est double. Rendre compte d'une expérience artistique « participative » que nous conduisons depuis 9 ans au secteur Musiques et Sciences de la Musique d'Aix-Marseille Université : Architectures Contemporaines est un festival universitaire de jeunes - Musique et Musicologie – GALERIE – Nouvel article.

This study aims to investigate the relationship between job burnout and employee performance in the feed industry during the ASF outbreak. Further, the researchers employed a descriptive-correlational research design in order to analyze the acquired data and produce pertinent findings. Thus, the researchers gathered data from one hundred two (102) feed industry employees. The Maslach Burnout Inventory (MBI) and Individual Work Performance Questionnaire (IWPQ) were employed to ascertain the extent of job burnout experienced by the respondents and evaluate employee performance, (...) respectively. Based on the statistical analysis, there is a significant relationship between job burnout and employee performance. Moreover, the study's findings were thoroughly analyzed and discussed. (shrink)

In this paper we shall introduce two types of contextual-hierarchical approaches to the strengthened liar problem. These approaches, which we call the ‘standard’ and the ‘alternative’ ch-reconstructions of the strengthened liar problem, differ in their philosophical view regarding the nature of truth and the relation between the truth predicates T r n and T r n+1 of different hierarchy-levels. The basic idea of the standard ch-reconstruction is that the T r n+1-schema should hold for all sentences of \. In contrast, (...) the alternative ch-reconstruction, for which we shall argue in section four, is motivated by the idea that T r n and T r n+1 are coherent in the sense that the same sentences of \ should be true according to T r n and T r n+1. We show that instances of the standard ch-reconstruction can be obtained by iterating Kripke’s strong Kleene jump operator. Furthermore, we will demonstrate how instances of the alternative ch-reconstruction can be obtained by a slight modification of the iterated axiom system KF and of the iterated strong Kleene jump operator. (shrink)

In spite of strengthened financial regulation, ethical concern continues about the promotion and distribution of financial services in Britain, including savings and investment products. Greater ethical attention needs to be paid to products, price, promotion and distribution. The authors are all faculty members of the School of Management and Finance, University of Nottingham, University Park, Nottingham NG7 2RD, UK. Correspondence should be addressed to Dr Ennew. Alison McGregor gratefully acknowledges funding provided by the Association of British Insurers.

Adaptation to changing and new environmental conditions is of fundamental importance to sustainability and requires concerted efforts amongst science, policy, and practice to produce solution-oriented knowledge. Joint knowledge production or co- production of knowledge has become increasingly popular terms to describe the process of scientists, policy makers and actors from the civil society coming together to cooperate in the production, dissemination, and application of knowledge to solve wicked problems such as climate change. Networks are particularly suited to produce knowledge in (...) a joint fashion. However, the process of joint knowledge production (JKP) in networks has rarely been examined. In this paper, we present a sketch of the adaptation network landscape and assess how joint knowledge production supports the development of solution-oriented knowledge in climate change adaptation networks. We conclude that the processes of JKP are diverse, complex, and highly dependent on the interests and roles of actors within the network. To keep such processes alive, signposts in form of analysis and intermediary products along the network lifetime should be positioned as means of stocktaking and monitoring for the future. (shrink)

Purpose/methods: This study investigated the relationship between ethics education and training, and the use and usefulness of ethics resources, confidence in moral decisions, and moral action/activism through a survey of practicing nurses and social workers from four United States (US) census regions. Findings: The sample (n = 1215) was primarily Caucasian (83%), female (85%), well educated (57% with a master's degree). no ethics education at all was reported by 14% of study participants (8% of social workers had no ethics education, (...) versus 23% of nurses), and only 57% of participants had ethics education in their professional educational program. Those with both professional ethics education and in-service or continuing education were more confident in their moral judgments and more likely to use ethics resources and to take moral action. Social workers had more overall education, more ethics education, and higher confidence and moral action scores, and were more likely to use ethics resources than nurses. Conclusion: Ethics education has a significant positive influence on moral confidence, moral action, and use of ethics resources by nurses and social workers. (shrink)

Dans cette réplique à l’article de Frank Jankunis, «Overall and Larmer on Miracles as Evidence for the Existence of God», je traite du concept de miracle comme violation de la loi naturelle. Je soutiens que, s’il advenait un miracle, ce serait un mal épistémique, ontique et moral, et, par conséquent, une preuve qu’il n’existe pas de Dieu parfait.

THIS ESSAY EXAMINES GLOBAL WATER PRIVATIZATION EFFORTS IN LIGHT of the environmental teachings of both Islam and Christianity, proposing that although environmental ethics is more developed within Christianity, Islam offers more ethical sources for thinking about water due to the arid climate in which Islam developed. Furthermore, this essay advocates full-cost pricing as necessary to attain closed loop water recycling, maintains that full-cost pricing does not further disadvantage the poor, and argues that full-cost pricing more easily fits Muslim and Christian (...) moral imperatives than present water policies do. (shrink)

« Je t’aime moi non plus », le titre de la fameuse chanson de Gainsbourg reflète de manière exquise ce que la vie a de beau et d’amer à la fois. A défaut de traiter d’amour, cet ouvrage analyse les méandres de l’aide à sens unique. L’altruisme, ce comportement de don sans attente de retour de service, est abordé ici de manière scientifique et philosophique plutôt que poétique et littéraire. Un objectif est d’en traquer les mécanismes sous-jacents, ceux qui échappent (...) à tout romantisme et se traduisent souvent en calculs de coûts et bénéfices. Il s’agit également d’approfondir les diverses manières de comprendre et de pratiquer l’altruisme. Souvent considéré comme une des plus grandes vertus humaines, l’objet de nombreux écrits philosophiques et psychologiques, l’altruisme peut-il se trouver chez les abeilles et les marmottes ? Posez la question à un biologiste de l’évolution et il vous répondra « Mais oui, évidemment ! ». A première vue, une telle réponse est consternante mais nous verrons qu’à y regarder de plus près, les philosophes et les biologistes ne parlent pas exactement de la même chose en utilisant le même terme. L’hétérogénéité des disciplines intéressées à l’altruisme et des contextes théoriques dans lesquels il est utilisé en ont fait une notion extrêmement complexe et difficile à saisir. Au sein des différentes sciences sociales et du vivant, l’altruisme est un élément pivot dans trois débats dont cet ouvrage prend le temps de retracer les contours. Tantôt, l’altruisme se profile en danger (apparent) pour la théorie de l’évolution darwinienne (chap. 1), tantôt, il sert de cheval de bataille dans la croisade contre l’idéal de l’homo economicus si souvent prôné en économie (chap. 2 et 3), tantôt il est une énigme à découvrir dans les méandres de nos motivations intimes (chap. 3). Dans le cadre de ces différents débats, la notion d’altruisme prend des significations sensiblement différentes. Pour en rendre compte, l’ensemble de l’ouvrage s’articule autour d’une triple distinction fondamentale : l’altruisme peut être compris au sens biologique, comportemental ou psychologique. Chacune de ces notions est utilisée dans un contexte spécifique au sein de sciences qui ont leurs propres traditions et leurs propres débats internes. La structure de l’ouvrage est organisée en fonction de cette triple distinction. Le premier chapitre est consacré à l’altruisme biologique, définit en termes de valeur de survie et de reproduction (fitness) : un comportement est altruiste s’il a pour effet d’augmenter la fitness d’autrui aux dépens de sa propre fitness. L’observation de comportements altruistes au sein du monde animal a posé un des plus grands défis à la théorie de l’évolution depuis la publication de l’Origine des espèces. Des générations de biologistes se sont attelés à la tâche d’expliquer comment un comportement qui augmente la fitness biologique d’autres organismes aux dépends de la fitness de l’agent a pu être sélectionnée au fil de l’évolution. Nous verrons que c’est grâce aux travaux de William Hamilton et d’autres que cette difficulté a pu être résolue. Le deuxième chapitre retrace les attaques d’une frange d’économistes (supportés dans leur effort critique par des théoriciens des jeux et anthropologues évolutionnistes), contre le modèle classique de l’homo economicus. Leur objectif est de montrer que des personnes ordinaires ne se comportement souvent pas en maximisateurs rationnels de leurs gains propres, comme le prédirait la théorie économique néo-classique. Dans le cadre de ce débat, c’est du comportement social spécifiquement humain et plus particulièrement de l’altruisme humain dont il est question. Le terme d’altruisme est alors utilisé dans un sens plus lâche que ne le font les biologistes ; ce que l’on appellera l’altruisme comportemental comprend les actions coûteuses pour l’agent et avantageuses pour autrui. La particularité humaine fournira également l’occasion de traiter la délicate question des rapports entre l’évolution génétique et la culture. Nous verrons que l’étude du comportement animal fournit les premiers éléments d’explication de l’altruisme humain, mais ce dernier ne peut être pleinement compris qu’au terme d’une analyse qui tient compte des capacités qui nous sont propres. Cette analyse nous permettra de saisir pourquoi les êtes humains sont à la fois plus sociaux et plus opportunistes (la contradiction n’est qu’apparente) que les autres espèces animales. Malgré leurs différences, les versions biologique et comportementale de l’altruisme sont très proches au sens où elles traitent des conséquences de comportements. Ces notions ne reflètent qu’imparfaitement la conception ordinaire que nous nous faisons de l’altruisme. L’altruisme tel qu’il est utilisé dans le langage courant correspond davantage à l’image que s’en font les philosophes et les psychologues. Pour déceler les actions altruistes, ces derniers se demandent généralement si elles ont été causées par un motif dirigé vers le bien d’autrui. En ce sens, on parle d’altruisme psychologique qui réfère aux causes plutôt qu’aux effets des actions d’aide. Le troisième chapitre est consacré aux débats qui font rage autour de la question de savoir si les êtres humains sont capables d’agir de manière altruiste psychologique, c’est-à-dire en fonction de motifs exclusivement dirigés vers le bien-être d’autrui. Nous verrons à quel point cette tâche est ardue à moins d’accepter de reformuler la question en termes de motivation primaire à l’action. Au terme de l’analyse, il apparaitra que les trois notions d’altruisme se croisent sans se recouper dans un enchevêtrement de liens plus ou moins complexes. Nous verrons par exemple que l’altruisme biologique (voire comportemental) pourrait bien être une condition nécessaire à l’évolution de l’altruisme psychologique ; des liens tangibles peut ainsi être tissés entre ces différentes notions. Les diverses approches du phénomène de l’altruisme retracées dans cet ouvrage fournissent également des clefs de compréhension des méandres du comportement social animal et plus particulièrement humain. De manière générale, sans apporter de solutions toutes faites, cet écrit peut servir de guide sémantique et initie le lecteur à une littérature interdisciplinaire émergeante, foisonnante, passionnante quoique encore souvent parsemée de confusions et de contradictions. (shrink)

L’étude menée sur les coupes de Droop attiques découvertes dans les fouilles de l’Artémision de Thasos a permis d’attirer notre attention sur un groupe de fragments décorés d’un thème peu fréquent sur cette forme : le retour d’Héphaïstos dans l’Olympe. Il n’est cependant pas rare sur d’autres classes de coupes contemporaines, en particulier sur les coupes à bande des Petits Maîtres dont la coupe de Droop est une variante. Mais si l’étude des fragments de l’Artémision permet de renforcer le lien (...) étroit existant dans la seconde moitié du vie s. av. J.‑C. entre la production des coupes à bande et celle des coupes de Droop, elle permet surtout de mettre en valeur une œuvre d’exception par la rareté de sa thématique, la qualité de son décor et ses dimensions généreuses. Son attribution au Peintre d’Oakeshott, proche compagnon du Peintre d’Amasis, lui confère une place privilégiée au sein des découvertes de céramiques attiques de l’île de Thasos. (shrink)

This article looks at the tensions experienced by teacher trainers in National Higher Institutes for Teaching and Education (Instituts nationaux supérieurs du professorat et de l'éducation ; INSPE), following the implementation of the reform of pre-service teacher training (beginning of the 2021 academic year). Thus, the positioning of competitive examinations at the end of the master's degree has led to the reorganization of training content. A questionnaire survey (n = 725) was conducted in spring 2022. Having defined the place and (...) role of trainers in the professional development of future teachers, the analyses highlighted the tensions present in the respondents' discourse. This latest reform, between continuity and change, has generated tensions with multiple sources and has forced many trainers to reconsider their activity, judging some of the prescribed measures as paradoxical. The resulting dilemmas have forced these trainers to rethink their priorities, to readjust their practices, and to reconsider their professionalism as well as the meaning of their activities. (shrink)

Le propos de l’article est l’analyse de la cérémonie de la prise d’habit au sein de l’Ordre Notre-Dame du Mont-Carmel aux xviie et xviiie siècles. À partir des sources normatives, picturales et hagiographiques, cette cérémonie est détaillée, notamment la scénographie de l’avant/après, gommant toute marque féminine (présence de cheveux, soins pour un teint pâle, vêtement ajusté, usage de soieries, de bijoux, etc.). Certaines pratiques témoignent de la mise en impatience de ce passage de la soie au drap, qui se traduit (...) par des prises d’habit clandestines, prématurées ou des portraits de mondaines usurpatrices en habit de carmélites. Il est vrai que le modèle absolu de La Madeleine, compte tenu des origines le plus souvent princières des postulantes, n’est pas étranger au prestige de la métamorphose. Réalité et construction représentative permettent de montrer comment le Carmel s’est approprié une cérémonie, qui, dans le contexte compétitif entre les ordres de la liturgie tridentine, valorise la femme, par le biais de la moniale, affranchie des attributs de son sexe. Mais surtout, la vêture a su rendre spectaculaire et désirable ce qui a priori ne l’est pas, la pauvreté et la pénitence du corps et de ses attributs, dans le but avoué du recrutement de nouvelles postulantes. De la rivalité entre drap et soie, le vainqueur n’est pas forcément celui que l’on croit. (shrink)

Sensitivity to others’ emotional signals is an important factor for social interaction. While many studies of emotional reactivity focus on facial emotional expressions, signals such as pupil dilation which can indicate arousal, may also affect observers. For example, observers’ pupils dilate when viewing someone with dilated pupils, so-called pupillary contagion. Yet it is unclear how pupil size and emotional expression interact as signals. Further, examining individual differences in emotional reactivity to others can shed light on its mechanisms and potential outcomes. (...) In the current study, adults’ (N = 453) pupil size was assessed while they viewed images of the eye region of individuals varying in emotional expression (neutral, happy, sad, fearful, angry) and pupil size (large, medium, small). Participants showed pupillary contagion regardless of the emotional expression. Individual differences in demographics (gender, age, socioeconomic status) and psychosocial factors (anxiety, depression, sleep problems) were also examined, yet the only factor related to pupillary contagion was socioeconomic status, with higher socioeconomic status predicting less pupillary contagion for emotionally-neutral stimuli. The results suggest that while pupillary contagion is a robust phenomenon, it can vary meaningfully across individuals. (shrink)

BackgroundThere is increasing need for peer reviewers as the scientific literature grows. Formal education in biostatistics and research methodology during residency training is lacking. In this pilot study, we addressed these issues by evaluating a novel method of teaching residents about biostatistics and research methodology using peer review of standardized manuscripts. We hypothesized that mentored peer review would improve resident knowledge and perception of these concepts more than non-mentored peer review, while improving review quality.MethodsA partially blinded, randomized, controlled multi-center study (...) was performed. Seventy-eight neurology residents from nine US neurology programs were randomized to receive mentoring from a local faculty member or not. Within a year, residents reviewed a baseline manuscript and four subsequent manuscripts, all with introduced errors designed to teach fundamental review concepts. In the mentored group, mentors discussed completed reviews with residents. Primary outcome measure was change in knowledge score between pre- and post-tests, measuring epidemiology and biostatistics knowledge. Secondary outcome measures included level of confidence in the use and interpretation of statistical concepts before and after intervention, and RQI score for baseline and final manuscripts.ResultsSixty-four residents (82%) completed initial review with gradual decline in completion on subsequent reviews. Change in primary outcome, the difference between pre- and post-test knowledge scores, did not differ between mentored (−8.5%) and non-mentored (−13.9%) residents (p = 0.48). Significant differences in secondary outcomes (using 5-point Likert scale, 5 = strongly agree) included mentored residents reporting enhanced understanding of research methodology (3.69 vs 2.61; p = 0.001), understanding of manuscripts (3.73 vs 2.87; p = 0.006), and application of study results to clinical practice (3.65 vs 2.78; p = 0.005) compared to non-mentored residents. There was no difference between groups in level of interest in peer review (3.00 vs 3.09; p = 0.72) or the quality of manuscript review assessed by the Review Quality Instrument (RQI) (3.25 vs 3.06; p = 0.50).ConclusionsWe used mentored peer review of standardized manuscripts to teach biostatistics and research methodology and introduce the peer review process to residents. Though knowledge level did not change, mentored residents had enhanced perception in their abilities to understand research methodology and manuscripts and apply study results to clinical practice. (shrink)

This paper takes a novel approach to studying the existence and stability of Nash equilibria in N-firm Cournot–Bertrand oligopolies. First, we show that such games can be monotonically embedded into a game of strategic heterogeneity, so that each firm best responds to the choices of all other firms in a monotonic way. We then show that this monotonicity can be exploited to derive conditions which guarantee the existence of a unique, dominance solvable Nash equilibrium which is stable under all adaptive (...) dynamics. These conditions constitute a strict improvement over existing results in the literature. Finally, we examine the effect on these conditions resulting from additional firms entering the market. (shrink)

IntroductionMilitary personnel and Veterans are at increased risk of mental and physical health conditions, which can impact their families. Spouses often perform a vital role in caring for service members and Veterans facing illness or injury, which can lead to caregiver burden. In turn, this may contribute to relationship issues. Research suggests that ensuring that spouses are well supported can alleviate some of these negative effects. The current study examined whether social support received by spouses of newly released Veterans buffers (...) the impact of Veterans’ health on caregiver burden, subsequently impacting spouses’ relationship satisfaction.MethodsData were collected as part of the Canadian Armed Forces Transition and Well-being Survey. The sample included N = 595 spouses of Regular Force Veterans who released in 2016 with at least 2 years of service. We examined Veterans’ mental and physical health and spouses’ caregiver burden, social support, and relationship satisfaction. A moderated mediation model was tested using structural equation modeling.ResultsThere was a significant indirect association between Veterans’ health and spouses’ relationship satisfaction through caregiver burden. Furthermore, social support moderated the association, as evidenced by a weaker association between Veterans’ health and caregiver burden at low levels of social support compared to high levels.ImplicationsFindings suggest additional efforts should be made to ensure sufficient support is provided to spouses, especially when they are caring for a service member or Veteran facing illness or injury, to strengthen their families’ well-being. (shrink)

Over the past decades, anti-cancer treatments have evolved rapidly from cytotoxic chemotherapies to targeted therapies including oral targeted medications and injectable immunooncology and cell therapies. New anti-cancer medications come to markets at increasingly high prices, and health insurance coverage is crucial for patient access to these therapies. State laws are intended to facilitate insurance coverage of anti-cancer therapies.Using Massachusetts as a case study, we identified five current cancer coverage state laws and interviewed experts on their perceptions of the relevance of (...) the laws and how well they meet the current needs of cancer care given rapid changes in therapies. Interviewees emphasized that cancer therapies, as compared to many other therapeutic areas, are unique because insurance legislation targets their coverage. They identified the oral chemotherapy parity law as contributing to increasing treatment costs in commercial insurance. For commercial insurers, coverage mandates combined with the realities of new cancer medications — including high prices and often limited evidence of efficacy at approval — compound a difficult situation. Respondents recommended policy approaches to address this challenging coverage environment, including the implementation of closed formularies, the use of cost-effectiveness studies to guide coverage decisions, and the application of value-based pricing concepts. Given the evolution of cancer therapeutics, it may be time to evaluate the benefits and challenges of cancer coverage mandates. (shrink)